Endocrine Abstracts

Background: Excess glucocorticoids are well recognised as a cause of osteoporosis; they inhibit osteoblast function and increase osteoblast and osteocyte apoptosis resulting in thinning of the trabeculae. The circadian rhythm of bone turnover, which is linked to cortisol rhythm, is abnormal in osteoporosis. Furthermore, some studies show abnormal cortisol metabolism in osteoporosis. The aim of our study was to evaluate the day–night rhythm of cortisol and to relate cortis...

Introduction: Cushing’s disease (CD) is a potentially fatal disease caused by corticotrophic adenoma of the pituitary gland. Crooke Cell Adenomas (CCA) are a rare variant characterized by cytoplasmic ring deposits of cytokeratin filaments. They are usually aggressive macroadenomas with a higher rate of recurrence and malignancy.Clinical case: A 36 year old man, with 34 kg weight gain and uncontrolled hypertension for 4 years presented at the Emerge...

Cortisol has a distinct circadian rhythm; levels rise from 0300 h to peak within an hour of waking and gradually decline until 1800 h before a quiescent period lasting from 1800 to 0300 h. Current hydrocortisone replacement regimens are unable to replicate this rhythm and we have been investigating modified release technology. Our initial formulation, using tableting technology, demonstrated it was possible to replicate the overnight rise in cortisol but the tablet had reduced...

Introduction: The discovery of incidental thyroid carcinomas (ITC) in patients undergoing surgery for a benign disease range between 3 and 16% of cases. During years, patients with hyperthyroidism were considered protected by TSH suppression (TSH is well known factor that favors the development of thyroid cancer). Thyroid size might be a predictive factor due to the excess of thyroid tissue prone to mutations. The knowledge of determining factors foretelling the presence of un...

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

Thyroid carcinoma is a rare extraintestinal manifestation of colonic familial adenomatous polyposis (FAP). This syndrome is caused by germline mutations in adenomatous polyposis coli (APC) gene, on chromosome 5q21-q22. Many patients manifest various extracolonic features: upper gastrointestinal adenomas, congenital hypertrophic retinal pigment epithelial lesions, desmoids tumors, and thyroid, adrenal and brain cancers. It has been reported an incidence of 1.2% of thyroid carci...

Introduction: Thyroglobulin (TG) measurement in fine needle aspirates cytology (FNAC) needle washout has become an important method for diagnostic of cervical lymph nodes, particularly in patients with differentiated thyroid cancers, but also in some patients before the diagnostic. We report some clinical cases to confirm its importance in these situations.Patients and methods: In our department we use this method since 2007. We report seven patients wit...

Aims: Our aim is to retrospectively analyze the diagnosis of hyponatremia in the discharge sheets of a tertiary hospital during 5 years and its relationship with type 1 and 2 diabetes mellitus.Methods: Data from the MBDS (Minimum Basic Data Set) of the discharged patients from the Hospital Clínico San Carlos (Madrid) between the years 2005 to 2009 was analysed. The 5th Edition of the ICD-9-CM was used for the codification of the diagnoses and proced...

Background: SDH mutations cause about 80% of familial pheochromocytomas / paragangliomas (1). Although mutations in each subunit are associated with a particular clinical spectrum of disease, there is no clear genotype-phenotype correlation of a specific mutation, nor with penetrance of disease. We report characteristics of patients with SDH mutations seen in a single dedicated tertiary referral clinic.Methods: A retrospective observational study of pati...